【藥物名稱】商品名：莽草酸
通用名：拜邦蟬聯(lián)莽草酸（禽流感克星）
【主要成分】苦杏仁、石膏、麻黃、洋金花。
【性 狀】類白色精細(xì)粉末，易溶于水，在水中的溶解度為18g/100mL，難溶于氯仿、苯和石油醚，氣味辛酸，味苦。
【分子結(jié)構(gòu)】化學(xué)式：3,4,5-三羥基-1-環(huán)己烯-1-羧酸 分子式： C7H10O5分子量：174.15 。
【功 能】止咳、平喘、清熱解毒、辛涼解表、等提高免疫力。
【主 治】本品為抗病毒類藥。適用于雞、鴨、鵝、豬，對(duì)各種DNA和RNA病毒性疾病均有較強(qiáng)抑制作用，特別對(duì)由H5N1、H9N2等亞型流感病毒引起的流行性感冒有治療和預(yù)防的作用。
主要用于防治禽流行性感冒、傳染性支氣管炎、傳染性喉氣管炎、新城疫、傳染性法氏囊、鴨肝、鴨瘟、脾壞死、副粘病毒、豬流感、豬瘟、等病毒性疾病。尤其對(duì)病毒病和細(xì)菌病混合感染（如氣囊炎�。┋熜Т_切。采食下降、精神沉郁、甩頭、流淚、咳嗽、呼嚕、呼吸困難、肢體癱瘓、站立不穩(wěn)、排黃白綠色糞便產(chǎn)蛋率下降等。
【產(chǎn)品特點(diǎn)】莽草酸可以直接通過影響花生四烯酸代謝，抑制血小板聚集，抑制動(dòng)、靜脈血栓及腦血栓形成發(fā)揮作用，莽草酸還具有抗炎、鎮(zhèn)痛作用。莽草酸可以作為抗病毒和抗癌藥物中間體，在體內(nèi)莽草酸還可轉(zhuǎn)化為多種對(duì)病毒、細(xì)菌和癌細(xì)胞有抑殺作用的物質(zhì)。 風(fēng)靡全球達(dá)菲就是通過莽草酸進(jìn)一步衍生化得到的。專家稱這是世界上對(duì)付禽流感的唯一
武器。因其口服吸收好，生物利用度高，抗病毒效果可靠。
全面替代金剛烷胺，安全高效，療效是金剛烷胺的3—5倍。本產(chǎn)品絕不含利巴韋林、金剛烷胺等國(guó)家禁用抗病毒藥物亦不含地米、撲爾敏、吲哚美辛等解表藥物，是養(yǎng)殖首選，可用于出口雞場(chǎng)、豬場(chǎng)。
流感病毒在宿主細(xì)胞內(nèi)復(fù)制表達(dá)和組裝之后，會(huì)以出芽的形式突出宿主細(xì)胞，但與宿主細(xì)胞以凝血酶-唾液酸相連接，神經(jīng)氨酸酶以唾液酸為作用底物，可催化唾液酸水解，解除成熟病毒顆粒與宿主細(xì)胞之間的聯(lián)系，使之可以自由移動(dòng)侵襲其他健康的宿主細(xì)胞。如果抑制神經(jīng)氨酸酶的活性可以阻止病毒顆粒的釋放，切斷病毒的擴(kuò)散鏈，從而抑制病毒的復(fù)制。在發(fā)病后24小時(shí)內(nèi)使用，病程會(huì)減短20%-30%，病情會(huì)減輕25%，作為預(yù)防用藥，對(duì)流感病毒暴露者的保護(hù)率在60%-80%之間。另外還可以通過阻斷病毒的糖蛋白合成及抑制病毒成熟后從細(xì)胞的釋放達(dá)到抗病毒效果。
口服迅速被吸收，進(jìn)入血液循環(huán)，2～3小時(shí)后達(dá)血藥峰濃度，其在體內(nèi)可以定向分布至肺部、支氣管、鼻竇、中耳等部位。
【用法用量】混飲 禽、豬每袋兌水350kg連用3-5天。 混飼 禽、豬每袋拌料175kg連用3-5天。
【注意事項(xiàng)】 1. 本品極易吸潮，開袋后應(yīng)盡快用完。
2. 原料若有結(jié)塊，可于70℃烘干1h，粉碎過篩后使用。
【不良反應(yīng)】 暫無。
【規(guī) 格】 ≥98%；100g/瓶。
【貯 存】 遮光、密閉保存。
美國(guó)拜邦生物科技集團(tuán)有限公司 地址：南京市沿江工業(yè)開發(fā)區(qū)新華路
電話：025-81650492 招商熱線：18751886846
[medicine name] commodity name: shikimic acid
Common name: thanks to the state won the shikimic acid (avian influenza.)
[main ingredients] bitter almond, plaster, ephedra, Flos daturae.
[character] class fine white powder, soluble in water, solubility is 18g/100mL in water, insoluble in chloroform, benzene, and petroleum ether, smell of bitter, bitter taste.
[] the molecular structure of chemical formula: 3,4,5- three hydroxy -1- cyclohexene -1- carboxylic acid molecular formula: C7H10O5 molecular weight: 174.15.
[function] relieving cough and asthma, detoxification, pungent-cool diaphoretic, and improve immunity.
[treatment] this product for antiviral drugs. Suitable for chicken, duck, goose, pig, for both DNA and RNA viral disease inhibitory effect, especially for treatment and prevention of influenza caused by the H5N1, H9N2 subtype influenza virus effect. Mainly used for prevention and control of avian influenza, infectious bronchitis, infectious laryngotracheitis, Newcastle disease, infectious bursal, duck, duck plague, spleen necrosis, paramyxovirus, swine flu, swine fever, viral diseases such as. Especially for viral and bacterial diseases of mixed infections (such as airsacculitis disease) curative effect. Food intake decreased, depression, shook his head, tears, cough, difficulty breathing, snoring, paralysis of limbs, standing instability, rows of yellow and white green manure laying rate drop.
[features] shikimic acid can be directly affected by four arachidonic acid metabolism, inhibit platelet aggregation, inhibit, venous thrombosis and cerebral thrombosis play a role, shikimic acid also has anti-inflammatory, analgesic effect. Shikimic acid can be used as antiviral and anticancer drug intermediates, in vivo shikimic acid can also be converted into a wide variety of viruses, bacteria and cancer cells to kill the substance. Swept the world of Tamiflu is through further derivatization of shikimic acid. Experts say this is the only weapon against avian influenza. Because of its good oral absorption, high bioavailability, antiviral effect is reliable.
Replace amantadine, high safety, efficacy is 3 - 5 times the amantadine. This product contains no ribavirin, amantadine and other countries banned antiviral drugs also does not contain more meters, chlorpheniramine, indomethacin, diaphoretic drug, is the culture choice, can be used for export of farms, pig farms.
After influenza virus replication in host cells expression and assembly, to host cells form prominent budding, but with the host cells to thrombin - sialic acid is connected, neuraminidase to sialic acid as substrate, can catalyze the sialic acid hydrolysis, releasing between mature virus particles and host cell contact, which can move freely invasion other healthy host cells. If the inhibition of neuraminidase activity can prevent the release of virus particles, to cut off the spread of the virus, thereby inhibiting virus replication. In 24 hours after the onset, duration will shorten 20%-30%, disease will be reduced by 25%, as a preventive medication, the influenza virus exposure protection rate was 60%-80%. Can also be through blocking and inhibiting virus glycoprotein synthesis of virus maturation from cells can release the antiviral effect in addition.
Oral is rapidly absorbed, enter the blood circulation, 2 ~ 3 hours after the peak plasma concentration, the directional distribution to the lungs, bronchial, sinus, middle ear and other parts of the body.
[usage] mix of avian, swine each bag exchange water 350kg 3-5 day. Mixed feeding poultry, pigs each bag of mixing 175KG 3-5 day.
[note] 1 the hygroscopic, open the bag should run out as soon as possible.
2 raw material if there is agglomeration, in 70 ℃ drying 1H, crushed and sieved using.
[] no adverse reaction.
[Specification] = 98%; 100g/ bottle.
[storage] shading, airtight preservation.
The United States of America thanks to the state of Biological Technology Group Co., Ltd.
議.gif)
